A new study in mice sheds light on at least part of the reason for the insulin resistance that can come from diets high in high-fructose corn syrup, a sweetener found in most sodas and many other processed foods.
Fructose is much more readily metabolized to fat in the liver than glucose, and in the process can lead to nonalcoholic fatty liver disease. NAFLD in turn leads to hepatic insulin resistance and type II diabetes.
Researchers showed that mice fed a high-fructose diet could be protected from insulin resistance if a gene known as transcriptional coactivator PPARg coactivator-1b (PGC-1b) was "knocked down" in the animals' liver and fat tissue. PGC-1b controls the activity of several other genes, including one responsible for building fat in the liver. This suggests an important role for PGC-1b in the pathogenesis of fructose-induced insulin resistance.Sources:
It is well established that fructose is more lipogenic than glucose, and high-fructose diets have been linked to hypertriglyceridemia, nonalcoholic fatty liver disease (NAFLD), and insulin resistance”
this study does
nothing to further the return to a more sane approach to health, but
will likely just create even more problems as they propose their
findings could lead to yet another drug treatment to hamper the harmful
effects of HFCS consumption.
How Much High Fructose Corn Syrup is in Your Diet?
The obesity and diabetes epidemics are no surprise when you consider the fact that the number one source of calories in America is high fructose corn syrup in soda.
are about 40 grams of HFCS per can
– more than the American Medical Association’s
maximum for ALL caloric sweeteners. And that’s without adding
the corn syrup now found in every type of processed, pre-packaged food
you can think of.
Why High Fructose Corn Syrup IS Worse For You than Sugar
you need to lose weight, or if you want to avoid diabetes and heart
disease, fructose is one type of sugar you’ll want to avoid,
particularly in the form of high-fructose corn syrup.
Part of what makes HFCS such a dangerous sweetener is that it is metabolized to fat in your body far more rapidly than any other sugar.
According to Dr. Elizabeth Parks, associate professor of clinical nutrition at UT Southwestern Medical Center and lead author of a study on fructose, published in the Journal of Nutrition just last year:
"Our study shows for the first time the surprising speed with which humans make body fat from fructose. Once you start the process of fat synthesis from fructose, it's hard to slow it down. The bottom line of this study is that fructose very quickly gets made into fat in your body."
This occurs because most fats are formed in your liver, and when sugar enters your liver, it decides whether to store it, burn it or turn it into fat. Fructose, however, bypasses this process and simply turns into fat.Additionally, there’s hard empirical evidence showing that refined man-made fructose like HFCS metabolizes to triglycerides and adipose tissue, not blood glucose. And one of the most thorough scientific analyses published to date on this topic found that fructose consumption leads to decreased signaling to your central nervous system from the hormones leptin and insulin.Because insulin and leptin act as key signals in regulating how much food you eat, as well as your body weight, this suggests that dietary fructose may contribute to increased food intake and weight gain.Decreased insulin and leptin signaling is also a main cause of diabetes and a host of other obesity-related conditions.
How HFCS Contributes to Diabetes
In addition to everything already mentioned -- including these latest findings that HFCS consumption can lead to nonalcoholic fatty liver disease, followed by hepatic insulin resistance and then type 2 diabetes -- research reported at the 2007 national meeting of the American Chemical Society, found evidence that soft drinks sweetened with HFCS may contribute to the development of diabetes because it contains high levels of reactive compounds that trigger cell and tissue damage that cause diabetes.Chemical tests among 11 different carbonated soft drinks containing HFCS were found to have ‘astonishingly high’ levels of reactive carbonyls. Reactive carbonyls are undesirable and highly-reactive compounds associated with “unbound” fructose and glucose molecules, and are believed to cause tissue damage.
How HFCS Contributes to Heart Disease
is also known to significantly raise your triglycerides
and LDL (bad cholesterol). Triglycerides, the chemical form of fat
found in foods and in your body, are not something you want in excess
Intense research over the past 40 years has confirmed that elevated blood levels of triglycerides, known as hypertriglyceridemia, puts you at an increased risk of heart disease.
Additional Health Dangers of High Fructose Corn Syrup
if all of that wasn’t bad enough, fructose also does not
enzymes, vitamins or minerals so it takes these micronutrients from
your body while it assimilates itself for use.
GMO corn will radically increase your risk of developing corn allergies. The problem with corn allergies are that once you have a corn allergy from GMO corn you will have an allergy to even healthy organic corn products.
How You Can Drastically Improve Your Overall Health
If you want to drastically improve your health, the answer is quite simple. To lose weight and reduce your risk of developing metabolic syndrome, diabetes, and heart disease, STOP drinking soda and processed fruit juices. Switch to pure water as your beverage of choice and you will be well on your way to better health.To preserve your health you also need to focus your diet on whole foods based on your personal biochemistry, and, if you do purchase packaged foods, become an avid label reader and avoid foods that contain corn syrup as a main ingredient.